Grid Community Characteristics and their Relation to Grid Security

The size, dynamics, composition and similar characteristics of Grid Communities constitute important data for Grid security requirements gathering and analysis. Collaborative Grid Communities are especially important as they constitute an important part of grid usage modes and demonstrate the need for more advanced Grid security solutions very clearly. This document reports the results of a survey conducted in the Fall of 2002 among members of the Grid community as to understand the needs of grid user and grid application developer communities today, provide information on and typical modes-of-use, and elicit requirements for future grid security systems

The Virginia Tech Computational Grid: A Research Agenda

An important goal of grid computing is to apply the rapidly expanding power of distributed computing resources to large-scale multidisciplinary scientic problem solving. Developing a usable computational grid for Virginia Tech is desirable from many perspectives. It leverages distinctive strengths of the university, can help meet the research computing needs of users with the highest demands, and will generate many challenging computer science research questions. By deploying a campus-wide grid and demonstrating its effectiveness for real applications, the Grid Computing Research Group hopes to gain valuable experience and contribute to the grid computing community. This report describes the needs and advantages which characterize the Virginia Tech context with respect to grid computing, and summarizes several current research projects which will meet those needs

Complication rates of peripherally inserted central catheters vs implanted ports in patients receiving systemic anticancer therapy: A retrospective cohort study

While implanted port catheters ("PORTs") have historically been the standard device for intravenous systemic anticancer therapy, the use of peripherally inserted central catheters (PICCs) has increased continuously and reliable catheter selection guidelines are lacking. We compare complication rates of PORTs and PICCs in cancer treatment in a retrospective study of 3365 patients with both solid organ (n = 2612) and hematologic (n = 753) malignancies, between 2001 and 2021. 26.4% (n = 890) of all patients were treated via PICCs and 73.6% (2475) via PORTs. 20.7% (578) experienced a major catheter-related complication with a higher rate in PICCs than in PORTs (23.5% vs 14.9%, P < .001). Among major complications, infections and mechanical complications were more common in PICCs than in PORTs (11.9% vs 6.4%, P = .001, 7.3% vs 4.2%, P = .002), whereas the rate of thrombosis was similar (3.4% vs 3.0%, P = .9). While PORTs had a higher rate of periprocedural complications (2.7% vs 1.1%, P < .05), PICCs overall complication rate exceeded PORTs within 3 days from implantation. Median follow-up was 49 (PICC) and 60 weeks (PORT). PORTs are safer and therefore should be preferred in this setting regardless of catheter dwell time

Cardiovascular effects of metabolic syndrome after transplantation: convergence of obesity and transplant-related factors.

Children are at increased risk of developing metabolic syndrome (MS) after kidney transplantation, which contributes to long-term cardiovascular (CV) morbidities and decline in allograft function. While MS in the general population occurs due to excess caloric intake and physical inactivity, additional chronic kidney disease and transplant-related factors contribute to the development of MS in transplant recipients. Despite its significant health consequences, the interplay of the individual components in CV morbidity in pediatric transplant recipients is not well understood. Additionally, the optimal methods to detect early CV dysfunction are not well defined in this unique population. The quest to establish clear guidelines for diagnosis is further complicated by genetic differences among ethnic groups that necessitate the development of race-specific criteria, particularly with regard to individuals of African descent who carry the apolipoprotein L1 variant. In children, since major CV events are rare and traditional echocardiographic measures of systolic function, such as ejection fraction, are typically well preserved, the presence of CV disease often goes undetected in the early stages. Recently, new noninvasive imaging techniques have become available that offer the opportunity for early detection. Carotid intima-media thickness and impaired myocardial strain detected by speckle tracking echocardiography or cardiac magnetic resonance are emerging as early and sensitive markers of subclinical CV dysfunction. These highly sensitive tools may offer the opportunity to elucidate subtle CV effects of MS in children after transplantation. Current knowledge and future directions are explored in this review

Benign external hydrocephalus: a review, with emphasis on management

Benign external hydrocephalus in infants, characterized by macrocephaly and typical neuroimaging findings, is considered as a self-limiting condition and is therefore rarely treated. This review concerns all aspects of this condition: etiology, neuroimaging, symptoms and clinical findings, treatment, and outcome, with emphasis on management. The review is based on a systematic search in the Pubmed and Web of Science databases. The search covered various forms of hydrocephalus, extracerebral fluid, and macrocephaly. Studies reporting small children with idiopathic external hydrocephalus were included, mostly focusing on the studies reporting a long-term outcome. A total of 147 studies are included, the majority however with a limited methodological quality. Several theories regarding pathophysiology and various symptoms, signs, and clinical findings underscore the heterogeneity of the condition. Neuroimaging is important in the differentiation between external hydrocephalus and similar conditions. A transient delay of psychomotor development is commonly seen during childhood. A long-term outcome is scarcely reported, and the results are varying. Although most children with external hydrocephalus seem to do well both initially and in the long term, a substantial number of patients show temporary or permanent psychomotor delay. To verify that this truly is a benign condition, we suggest that future research on external hydrocephalus should focus on the long-term effects of surgical treatment as opposed to conservative management

Robust estimation of bacterial cell count from optical density

Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals &lt;1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data

The PRIMA Grid Authorization System Abbreviations API -Application Programming Interface CAS -Community Authorization Service GSS -Generic Security Services PDP -Policy Decision Point PEP -Policy Enforcement Point PRIMA -A system for Privilege Management

Abstract PRIMA, a system for PRIvilege Management and Authorization, provides enhanced grid security services. The requirements for these services are derived from usage scenarios and supported by a survey of grid users. The requirements for added flexibility, increased expressiveness, and more precise enforcement are met by a combination of three mechanisms: (1) use of secure, fine-grained privileges representing externalized access rights for grid resources that can be freely created, shared, and employed by grid users; (2) a dynamic policy generated for each request combining the request&apos;s user-provided privileges with the resource&apos;s access control policy; and (3) dynamic execution environments specially provisioned for each request that are enforced by the resource&apos;s native operating system and which support legacy applications. PRIMA has been implemented as an extension of the Globus Toolkit grid middleware